Revista SPA

Visão geral do tumor de células da granulosa em éguas

10.22579/22484817.882
Publicado 2022-06-30
Revisión de literatura

Resumo

Existem diferentes patologias ováricas que diminuem a capacidade reprodutiva das éguas onde são muito frequentes os processos neoplásicos ou tumores no ovário nas fêmeas equinas; sendo o tumor de células da granulosa (TCG) o de maior apresentação, correspondendo a 2,5% de todas as neoplasias presentes em equinos. O TCG representa um problema econômico em criatórios de alto valor genético devido ao tempo reprodutivo perdido na égua, aos altos custos de diagnóstico, tratamento e, em certas ocasiões, a necessidade de descarte de uma fêmea reprodutora. Devido à sua alta incidência na indústria equina no país e no mundo, é importante ter informações fisiopatológicas atualizadas que possibilitem decisões terapêuticas baseadas em evidências científicas. O objetivo deste artigo foi fazer uma revisão sistemática sobre TCG em éguas. Para isso, foram buscadas informações em diversas bases de dados, utilizando palavras de busca como: granulosa cell tumors in mares, granulosa cell tumors in mares, ovarian pathologies in mares e pathophysiology of granulosa cell tumors, ovarian pathologies in mares e physiopathology of granulose cell tumor. Por fim, o presente trabalho conclui que a fisiopatologia do TCG em éguas permanece incerta devido aos múltiplos fatores que podem estar envolvidos; e seu diagnóstico depende da associação de manifestações clínicas, exame ultrassonográfico, resultados do perfil hormonal e histopatologia.

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Ali A, Al-Sobayill A, Tharwat M, Mehana E, & Al-Hawas A. Granulosa cell tumour in a female dromedary camel. Comparative Clinical Pathology, 2013;22(6):1251–1254. https://doi.org/10.1007/s00580-013-1755-z

Ali A, Alamaary M, Al-Sobayill F, Mehana E, & Fathy A. Ovarian tumours in Arabian mares. Comparative Clinical Pathology, 2015;24(1):157–162. https://doi.org/10.1007/s00580-013-1877-3

Almeida J., Ball A., Conley A. J., Place N. J., Liu I. K. M., Scholtz E. L., Mathewson L., Stanley S. D., Moeller B. C. Biological and clinical significance of anti-Müllerian hormone determination in blood serum of the mare. Theriogenology, 2011;76(8):1393–1403. Disponible en: https://doi.org/10.1016/j.theriogenology.2011.06.008

Amrozi A., Melia J., Parwati L., Tumbelaka L. I. T. A. Prevalence of Mares’ Granulosa Theca Cell Tumor (Gtct) in Indonesia. Jurnal Kedokteran Hewan - Indonesian Journal of Veterinary Sciences, 2020;13(4):98–100. https://doi.org/10.21157/j.ked.hewan.v13i4.12797

Amrozi A., Soehartono R., Adistya E., Mahardi I., Mukarromah H., SATRIA M. I., WAI, H. RAVI S. Removal of granulosa theca cells tumor in the mare. ARSHI Veterinary Letters, 2020;4(1):11-12. https://doi.org/10.29244/avl.4.1.11-12

Ball B. A., Almeida J., Conley A. J. Determination of serum anti-Müllerian hormone concentrations for the diagnosis of granulosa-cell tumours in mares. Equine Veterinary Journal, 2013;45(2):199-203. https://doi.org/10.1111/j.2042-3306.2012.00594.x

Boerboom D, Paquet M, Hsieh M, Liu J, Jamin S. P, Behringer R. R, Sirois J., Taketo M. M, Richards J. A. S. Misregulated Wnt/β-catenin signaling to ovarian granulosa cell tumor development. Cancer Research, 2005;65(20):9206-9215. https://doi.org/10.1158/0008-5472.CAN-05-1024

Castillo J, Tse M. P, Dockweiler J, Cheong S, Amorim M. D. Case Report Rapport de cas Bilateral granulosa cell tumor in a cycling mare. 2019. 60(May).

Chavarria Rivera, J. Patologías ováricas en equinos (Equus ferus caballus) de alto valor genético en ranchos de criadores de los departamentos de Managua, Masaya y Chinandega en el periodo Julio 2012- Julio 2013.

Conley A. J, Scholtz E. L, Dujovne G, Cotterman R. F, Legacki E. L, Uliani R. C, Alvarenga M. A, Ball B. A, Karla B, Savjani G. V, Kumar A. Inhibin-A and inhibin-B in cyclic and pregnant mares, and mares with granulosa-theca cell tumors: Physiological and diagnostic implications. Theriogenology, 2018;108:192-200. https://doi.org/10.1016/j.theriogenology.2017.12.003

Cortés Z, Aréchiga C, Rincón M, Rochín F, López M, Flores G. Revisión: El Ciclo Reproductivo de la Yegua. Abanico Veterinario, 2018;8(3):14-41. https://doi.org/10.21929/abavet2018.83.1

Crabtree J. Papers Review of seven cases of granulosa cell tumour of the equine ovary. 2011. https://doi.org/10.1136/vr.d4635

Crabtree J. Can ovariectomy be justified on grounds of behaviour ? Vet Times. 2014. https://www.vettimes.co.uk

Crabtree J. R, Brennan M. J, Foote A. K, Pycock J. F. Granulosa cell tumour: An interesting case in a pregnant mare. Equine Veterinary Education, 2013;25(1):4-10. https://doi.org/10.1111/j.2042-3292.2011.00361.x

De Macedo G C, Pereira N. N, Gomes W. T, De Andrade G. B, Miraglia H, Vilela Campos J. B. Tumor de células da granulosa em égua: relato de caso granulosa cell tumor. EBSCOhost. Archives of Veterinary Science. 2016. Disponible en: http://webebsco.unillanos.elogim.com/ehost/detail/detail?vid=9&sid=9b1ffa9a-3bc5-4357-88b4-4e914654aa0f%40sdc-v-sessmgr03&bdata=Jmxhbmc9ZXMmc2l0ZT1laG9zdC1saXZl#db=asn&AN=119801367

Ellenberger C, Bartmann C. P, Hoppen H. O, Kratzsch J, Aupperle H, Klug E, Schoon D, Schoon, H. A. Histomorphological and immunohistochemical characterization of equine granulosa cell tumours. Journal of Comparative Pathology, 2007;136(2-3):167-176. https://doi.org/10.1016/j.jcpa.2007.01.011

Franco J, Uribe Velásquez, L. F. Reproductive hormones of veterinary importance in domestic ruminant females. Biosalud. 2012. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1657-95502012000100006&lng=en&nrm=iso&tlng=es

Frederico L M, Gerard M P, Pinto C R F, Gradil C M. Bilateral occurrence of granulosa-theca cell tumors in an Arabian mare. Canadian Veterinary Journal, 2007;48(5):502-505.

Gharagozlou F, Youssefi R, Akbarinejad V, Ashrafihelan J. Elevated serum anti-müllerian hormone in an arabian mare with granulosa cell tumor. Journal of Equine Veterinary Science, 2013;33(8):645-648. https://doi.org/10.1016/j.jevs.2012.09.003

Gharagozlou F, Youssefi R, Akbarinejad V, Masoudifard M, Ashrafihelan J. Changes of serum anti-Müllerian hormone in a mare with granulosa cell tumour following surgery and reinitiation of follicular activity. Equine Veterinary Education, 2014;26(9):481-484. https://doi.org/10.1111/eve.12170

Gündüz M, Kaşikçi G, Kiliçarslan R, Uçmak M, Düzgün O, Tek Ç. Reproductive performance following unilateral ovariectomy for treatment of ovarian tumors in 7 mares. Turkish Journal Of Veterinary And Animal Sciences, 2010;34(3):283–287. https://doi.org/10.3906/vet-0812-20

Hendrickson, D. A. A. Review of Equine Laparoscopy. ISRN Veterinary Science, 2012,1-17. https://doi.org/10.5402/2012/492650

Hoque M, Derar R, Tsunoda N, Senba H, Osawa T, Miyake Y. Clinical findings before and after the removal of ovaries affected with granulosa theca cell tumor (GTCT) in 16 mares. Journal of Equine Science, 2002;13(3):75-81. https://doi.org/10.1294/jes.13.75

Hughes, L. (n.d.). Granulosa Cell Tumors in the Mare. Retrieved May 11, 2021, from www.newenglandequine.com

Hyatt J, Hanlon D, Hollinshead F. Anti-Müllerian Hormone - a new test for the diagnosis of Granulosa Cell Tumours in mares. CVE Control & Therapy Series, 2015;279:9-10.

Kim SInsights into granulosa cell tumors using spontaneous or genetically engineered mouse models. 2016;43(1):1-8.

Korany M. S, Derbala K, Mosallam E, Fadel M, Aly H, Essmail M. E Diagnosis of granulosa cell tumors in arabian mares by ultrasonography, hormonal profile and histopathology. Advances in Animal and Veterinary Sciences, 2020;8(3):327-332. https://doi.org/10.17582/journal.aavs/2020/8.3.327.332

Liebig E, Davis A, Klohonatz M, Graham E, Hendrickson A, Easley T, Hackett S, Pinedo J, Eckery C, Bruemmer E. Circulating and Cultured Anti-Müllerian Hormone Concentrations Following Hemi-ovariectomy in Anestrous Mares. Journal of Equine Veterinary Science,2018;66:118. https://doi.org/10.1016/j.jevs.2018.05.163

Maclachlan N. J, Kennedy P. C. Tumors of the Genital Systems. In Tumors in Domestic Animals, Lowa State Press, 2008;547-573. https://doi.org/10.1002/9780470376928.ch11

Maurice K. T. Diagnosis and surgical removal of a granulosa-theca cell tumor in a mare. 2005;46(July):0-2.

Mccue P, Roser J, Munro C, Liu I K, Lasley B. Granulosa Cell Tumors of the Equine Ovary. 2006;22:799-817. https://doi.org/10.1016/j.cveq.2006.08.008

Mccue, P. M. (2013). Granulosa Cell Tumor in a Mare. 3;1-7.

Melgaard D, Korsgaard T, Thoefner M, Petersen M, Pedersen H. Moody mares—Is ovariectomy a solution? Animals, 2020;10(7):1-11. https://doi.org/10.3390/ani10071210

Miguez S, Bizarro Da Silva C, Zandonadi F, Romero G, Silva K. Marcondes M. Granulosa cells tumor in mules. Revista Acadêmica Ciência Animal, 2015;13(0). https://doi.org/10.7213/academica.13.fc.ao09

Mihm M, Bleach E. C. L. Endocrine regulation of ovarian antral follicle development in cattle. Animal Reproduction Science, 2003;78(3-4):217-237. https://doi.org/10.1016/S0378-4320(03)00092-7

Moher D, Liberai A, Tetzlaff J, Altman D. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. In BMJ (Online) British Medical Journal Publishing Group. 2009;339(7716):332-336. https://doi.org/10.1136/bmj.b2535

Mora V, Fuentes E, Góngora A. Diagnóstico y tratamiento de un tumor de células de la granulosa en una yegua criolla colombiana. Redalyc.Org, 2004;8(2):42-48. http://www.redalyc.org/articulo.oa?id=89680204

Moya C F, Carmo M T, Merlini G P, Araujo G H M. Perfil hormonal de égua com tumor das células da granulosa-teca. In Inovação e Pluralidade na Medicina Veterinária, Atena Editora. 2020;3:86-91. https://doi.org/10.22533/at.ed.84520110812

Müller K, Ellenberger C, Hoppen H O, Schoon H A. Immunohistochemical study of angiogenesis and angiogenic factors in equine granulosa cell tumours. Research in Veterinary Science, 2012;92(3):471-477. https://doi.org/10.1016/j.rvsc.2011.02.016

Munkhtuul T, Murase H, Ball B, Habukawa K, Sato F, Watanabe K, Nambo Y. Immunolocalization of anti-Müllerian Hormone and Its Receptor in Granulosa Cell Tumors in Mares. Journal of Equine Veterinary Science, 2019;74:9-12. https://doi.org/10.1016/j.jevs.2018.12.012

Murase H, Ball B, Tangyuenyong S, Watanabe G, Sato F, Hada T, Nambo Y. Serum Anti-Müllerian Hormone Concentrations in Mares With Granulosa Cell Tumors Versus Other Ovarian Abnormalities. Journal of Equine Veterinary Science, 2018;60:6-10. https://doi.org/10.1016/j.jevs.2017.10.012

Patrick D, Kiupel M, Gerber V, Carr E. Malignant granulosa-theca cell tumor in a two-year-old miniature horse. Journal of Veterinary Diagnostic Investigation, 2003;15(1):60-63. https://doi.org/10.1177/104063870301500114

Petrizzi L, Guerri G, Straticò P, Cuomo A, Vullo C, De Amicis I, Robbe D, Varasano V. Laparoscopic Ovariectomy in Standing Mule Mares. Journal of Equine Veterinary Science, 2020;84. https://doi.org/10.1016/j.jevs.2019.102857

Pinna A, Okada C, Ferreira C, Campos R, Possidente K, Morais R, Oliveira M, Salomão M, Hataka A. Double ovarian tumour in the mare: Case report. Reproduction in Domestic Animals, 2019;54(6):912–916. https://doi.org/10.1111/rda.13433

Prestes N, Nogueira De Moraes C, Maia L, De Oliveira I, Sousa Fabris V, Alvarenga M. Ovarian Tumor in a Mare-Thecoma-Case Report. Journal of Equine Veterinary Science, 2013;33(3):196–200. https://doi.org/10.1016/j.jevs.2012.06.007

Renaudin C, Kelleman A, Keel K, Mccracken J, Ball B, Ferris R, Mccue P, Dujovne G, Conley A. Equine granulosa cell tumours among other ovarian conditions : Diagnostic challenges. 2020:1–11. https://doi.org/10.1111/evj.13279

Röcken M, Mosel G, Seyrek K, Seyrek D., Litzke F, Verver J, Rijkenhuizen A. Unilateral and Bilateral Laparoscopic Ovariectomy in 157 Mares: A Retrospective Multicenter Study. Veterinary Surgery, 2011;40(8):1009–1014. https://doi.org/10.1111/j.1532-950X.2011.00884.x

Ruiz A, Rivera C, Calderon C, Franco A, Gomez D. Tumor de células de la granulosa: diagnóstico, tratamiento hormonal e intervención quirúrgica en yegua criolla colombiana. Revista Colombiana de Ciencia Animal - RECIA, 2013;5(2):527. https://doi.org/10.24188/recia.v5.n2.2013.462

Sherlock C, Lott K, Bergren A, Withers J, Fews D, Mair T. Granulosa cell tumours in the mare : A review of 52 cases. 2016;28:75-82. https://doi.org/10.1111/eve.12449

Smith L. Moody mares – ovariectomy in the horse. Veterinary Nursing Journal, 2012;27(3),109-111. https://doi.org/10.1111/j.2045-0648.2011.00115.x

Troedsson H, Mccue P, Macpherson L. Clinical aspects of ovarian pathology in the mare. Pferdeheilkunde, 2003;19(6):577-584

Trundelll D. Abnormalities of the mare’s ovaries. Livestock, 2017;22(5):278-281. https://doi.org/10.12968/live.2017.22.5.278

Vanderwall D, Rood K. How to Use Anti-Müllerian Hormone Testing to Diagnose Granulosa Cell Tumors in Mares. 2014:1-6.

Zelli R, Sylla L, Monaci M, Stradaioli G, Sibley L, Roser J, Munro C, Liu M. Gonadotropin secretion and pituitary responsiveness to GnRH in mares with granulosa-theca cell tumor.Theriogenology,2006;66(5):1210-1218. https://doi.org/10.1016/j.theriogenology.2006.03.030

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